Author

N. Cashman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Karsan· 2 shared G. Cole· 2 shared J. Gsponer· 2 shared J. Wang· 2 shared P. F. Lange· 2 shared T. Mayor· 2 shared C. M. Molzahn· 1 shared C. Molzahn· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

A. Karsan

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3 papers

Recent·Most cited

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

C. Molzahn, E. Kuechler, L. Nierves, G. Cole, J. Wang, N. Cashman, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.

bioRxiv · Feb 28, 2024 · PreprintCell Biology

Shift of the insoluble content of the proteome in aging mouse brain

C. M. Molzahn, E. R. Kuechler, I. Zemlyankina, L. Nieves, T. Ali, G. Cole, J. Wang, R. F. Albu, M. Zhu, N. Cashman, S. Gilch, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

This study identifies age-related changes in the insoluble proteome of mouse brains, showing a shift in protein characteristics associated with proteostasis decline.

bioRxiv · Dec 13, 2022Cell Biology

In Silico Determined Properties of Designed Superoxide Dismutase-1 Mutants Predict ALS-like Phenotypes In Vitro and In Vivo

M. G. DuVal, L. McAlary, M. Habibi, P. Garg, M. Sher, N. Cashman, W. T. Allison, S. S. Plotkin

The paper designs and tests SOD1 mutants using computational methods, showing that a destabilizing mutant causes ALS-like phenotypes while a stabilizing mutant rescues them in zebrafish.

bioRxiv · Nov 21, 2018 · PreprintBiophysics