Author

R. Steele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

I. Mills· 3 shared A. Pickard· 2 shared D. Mukherjee· 2 shared D. Waugh· 2 shared F. Amoroso· 2 shared K. Butterworth· 2 shared R. B. Ray· 2 shared R. Ray· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

I. Mills

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IRF7 impacts on prostate cancer cell survival in response to radiation

A. Pickard, F. Amoroso, K. McCulloch, A. Erickson, A. Sachdeva, R. Steele, D. Mukherjee, M. Dellett, J. McComb, L. McCaffrey, C. Hart, M. Brown, S. S. McDade, D. Waugh, N. Clarke, , I. Mills

This study investigates how IRF7 influences prostate cancer cell survival after radiation and identifies therapeutic vulnerabilities linked to IRF7 expression.

bioRxiv · Sep 23, 2022 · PreprintCancer Biology

Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells

S. Sur, r. steele, S. Isbell, R. Ray, R. B. Ray

This study shows that exosomes from severe COVID-19 patients activate the NLRP3 inflammasome in endothelial cells, leading to increased IL-1β secretion.

bioRxiv · Feb 3, 2022 · PreprintImmunology

Modulating the unfolded protein response: Impacts of radiation on the response of prostate cancer cells to ONC201

F. Amoroso, K. Glass, F. Liberal, R. Steele, S. Maguire, R. Tarapore, J. Allen, S. Van Schaeybroeck, K. Butterworth, K. Prise, J. O'Sullivan, S. Jain, D. Waugh, I. Mills

This study investigates how radiation and ONC201 modulate the unfolded protein response (UPR) in prostate cancer cells, enhancing cell death and radiosensitivity.

Scientific Reports · Feb 19, 2021Peer-reviewedCancer Biology

Exosomes from COVID-19 patients carry tenascin-C and fibrinogen-β in triggering inflammatory signals in distant organ cells

S. Sur, M. B. Khatun, R. Steele, S. Isbell, R. Ray, R. B. Ray

This study identifies tenascin-C and fibrinogen-β in exosomes from COVID-19 patients that trigger pro-inflammatory cytokine expression in distant organ cells.

bioRxiv · Feb 8, 2021Physiology

Development of a novel allograft model of prostate cancer: a new tool to inform clinical translation

C. Haughey, D. Mukherjee, R. Steele, A. Popple, L. Dura-Perez, A. Pickard, S. Jain, P. Mullan, R. Williams, P. Oliveira, N. Buckley, J. Honeychurch, S. S. McDade, T. Illidge, I. Mills, S. Eddie

This paper develops a novel allograft model of high-risk prostate cancer that mimics human disease features and responds to radiotherapy.

bioRxiv · Feb 16, 2020 · PreprintCancer Biology