Author

K. A. Helmin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Organism:mouse· 5 Assay:bulk RNA-seq· 4 Assay:DNA methylation· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3

Frequent Co-Authors

B. D. Singer· 6 shared H. Abdala-Valencia· 4 shared L. Morales-Nebreda· 3 shared M. A. Torres Acosta· 3 shared K. R. Anekalla· 2 shared N. S. Michki· 2 shared R. Piseaux· 2 shared S. A. McGrath-Morrow· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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6 shared papersImmunology

B. D. Singer

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6 papers

Recent·Most cited

AMP-activated protein kinase is necessary for Treg cell functional adaptation to microenvironmental stress

M. A. Torres Acosta, N. Mambetsariev, C. P. R. Flores, K. A. Helmin, Q. Liu, A. M. Joudi, L. Morales-Nebreda, J. Gurkan, K. Cheng, H. Abdala-Valencia, S. E. Weinberg, B. D. Singer

This study shows AMPK is necessary for Treg cell adaptation to metabolic stress in tumors and lung injury but not for baseline immune homeostasis.

bioRxiv · Nov 29, 2023 · PreprintImmunology

Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in ataxia telangiectasia

N. S. Michki, B. D. Singer, J. V. Perez, A. J. Thomas, V. Natale, K. A. Helmin, J. Wright, L. Cheng, L. R. Young, H. M. Lederman, S. A. McGrath-Morrow

This study uses bulk RNA-seq to identify inflammatory phenotypes in ataxia telangiectasia by analyzing peripheral blood mononuclear cells.

bioRxiv · Oct 5, 2023Immunology

DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia

N. S. Michki, R. Ndeh, K. A. Helmin, B. D. Singer, S. A. McGrath-Morrow

The paper shows that DNA methyltransferase inhibition in neonatal mice with E. coli pneumonia reduces methylation of interferon-responsive genes, shifting gene expression toward a juvenile-like profile.

bioRxiv · Sep 30, 2022 · PreprintImmunology

Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

L. Morales-Nebreda, K. A. Helmin, N. S. Markov, R. Piseaux, M. A. Torres Acosta, H. Abdala-Valencia, Y. Politanska, B. D. Singer

This study shows that aging impairs Treg cell function during recovery from influenza pneumonia, with transcriptional and DNA methylation changes contributing to reduced reparative capacity in aged mice.

bioRxiv · Jun 5, 2020Immunology

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

K. A. Helmin, L. Morales-Nebreda, M. A. Torres Acosta, K. R. Anekalla, S.-Y. Chen, H. Abdala-Valencia, Y. Politanska, P. Cheresh, M. Akbarpour, E. M. Steinert, S. E. Weinberg, B. D. Singer

This study shows that maintenance DNA methylation, regulated by Uhrf1, is essential for Treg cell development and stability of their suppressive function.

bioRxiv · Feb 3, 2020Immunology

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

A. C. McQuattie-Pimentel, Z. Ren, N. Joshi, S. Watanabe, T. Stoeger, M. Chi, Z. Lu, L. Sichizya, R. Piseaux, C.-I. Chen, S. Soberanes, P. A. Reyfman, J. M. Walter, K. R. Anekalla, J. M. Davis, , G. S. Budinger

This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.

bioRxiv · Jul 29, 2019 · PreprintImmunology