Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia
L. Morales-Nebreda, K. A. Helmin, N. S. Markov, R. Piseaux, M. A. Torres Acosta, H. Abdala-Valencia, Y. Politanska, B. D. Singer
This study shows that aging impairs Treg cell function during recovery from influenza pneumonia, with transcriptional and DNA methylation changes contributing to reduced reparative capacity in aged mice.
bioRxiv · Jun 5, 2020Immunology