L. Neahring

Torques within and outside the human spindle balance twist at anaphase

The paper investigates how molecular torques balance spindle twist during anaphase in human cells, identifying factors that increase or decrease twist.

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force

This study shows cyclin D1 overexpression increases spindle abnormalities but protects against pole fracture under compressive force, potentially aiding cancer cell survival in solid tumors.

Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

This study investigates how mammalian spindle length is maintained by showing that kinetochore-fibers can self-regulate their length without pole-focusing forces, but poles coordinate length across fibers.

Opposing motors provide mechanical and functional robustness in the human spindle

This study shows that opposing motors dynein and Eg5 are essential for the mechanical and functional robustness of human spindles, even though their inhibition allows bipolar spindle formation.