M. Richter

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

This study identifies epigenetic changes in AT2 cells from COPD patients that disrupt IFN and WNT pathways, impairing lung regeneration.

Cardiomyocyte mechanical memory is regulated through the talin interactome and DLC1 dependent regulation of RhoA

The paper identifies DLC1's role in regulating RhoA activity through the talin interactome, linking mechanical memory to cardiac phenotype changes.

Actin Y53 Phosphorylation Regulates Somatic F-actin Radial Translocation to Promote Neuronal Polarization

This study identifies actin Y53 phosphorylation as a regulator of somatic F-actin translocation, which influences neuronal polarization during axon formation.

Subgenome dominance shapes novel gene evolution in the decaploid pitcher plant Nepenthes gracilis

This study shows how subgenome dominance in the decaploid pitcher plant Nepenthes gracilis contributes to novel gene evolution linked to its carnivorous traits and dioecy.

Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

This study investigates how mammalian spindle length is maintained by showing that kinetochore-fibers can self-regulate their length without pole-focusing forces, but poles coordinate length across fibers.

High-resolution epigenetic profiling identifies novel regulators of COPD in human lung fibroblasts

This study identifies novel epigenetic and transcriptomic regulators of COPD in human lung fibroblasts across disease stages.

SARS-CoV-2 has not emerged in roe, red or fallow deer in Germany or Austria during the COVID 19 pandemic

The paper tests deer samples from Germany and Austria for SARS-CoV-2 exposure and finds no evidence of infection during the pandemic.

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

This study shows androgen signaling increases ACE2 levels, contributing to severe COVID-19 in men, and suggests androgen receptor inhibition as a potential treatment.

Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lung.

This paper develops a cryopreservation workflow for human lung tissue that maintains cell viability and omics profiles, enabling single-cell and bulk sequencing for studying lung diseases.