Author

L. Nierves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Organism:mouse· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

P. F. Lange· 5 shared A. C. Uzozie· 2 shared E. K. Ergin· 2 shared J. Tsui· 2 shared A. Karsan· 1 shared A. Lorentzian· 1 shared A. Uzozie· 1 shared C. A. Maxwell· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersCancer Biology

P. F. Lange

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5 papers

Recent·Most cited

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

C. Molzahn, E. Kuechler, L. Nierves, G. Cole, J. Wang, N. Cashman, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.

bioRxiv · Feb 28, 2024 · PreprintCell Biology

Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

L. Nierves, J. Guo, S. Chen, J. Tsui, A. C. Uzozie, J. W. Bush, T. Huan, P. F. Lange

This study compares bone marrow interstitial fluid and peripheral blood plasma in pediatric acute lymphoblastic leukemia, finding distinct metabolic, lipid, and protein profiles before and after chemotherapy.

bioRxiv · Mar 30, 2022Cancer Biology

Detectability of biotin tags by LC-MS/MS

L. Nierves, P. F. Lange

The paper compares two biotin labels to assess their impact on peptide detection by LC-MS/MS, finding that biotinylation increases hydrophobicity and reduces charge, requiring gradient optimization and inclusion of singly charged precursors.

bioRxiv · Dec 30, 2020Biochemistry

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

A. C. Uzozie, E. K. Ergin, N. Rolf, A. Lorentzian, S. S. Weng, L. Nierves, T. G. Smith, C. J. Lim, C. A. Maxwell, G. S. Reid, P. F. Lange

This study compares proteome and post-translational modification landscapes between pediatric leukemia patients and their xenograft models, finding both similarities and key divergences.

bioRxiv · Dec 18, 2019Cancer Biology

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

S. S. H. Weng, F. Demir, E. K. Ergin, S. Dirnberger, A. Uzozie, D. Tuscher, L. Nierves, J. Tsui, P. F. Huesgen, P. F. Lange

The paper introduces a method for identifying thousands of N-termini from small samples, demonstrating its application across various biological contexts.

bioRxiv · Mar 3, 2019Biochemistry