Author

T. Mayor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Research Focus:protein folding & dynamics· 4 Organism:mouse· 3 Organism:yeast· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Gsponer· 4 shared E. R. Kuechler· 3 shared M. Zhu· 3 shared A. Karsan· 2 shared G. Cole· 2 shared J. Wang· 2 shared N. Cashman· 2 shared P. F. Lange· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCell Biology

J. Gsponer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

C. Molzahn, E. Kuechler, L. Nierves, G. Cole, J. Wang, N. Cashman, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.

bioRxiv · Feb 28, 2024 · PreprintCell Biology

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations

H. A. Baker, J. P. Bernardini, V. Csizmok, A. Madero, S. Kamat, H. Eng, J. Lacoste, F. Yeung, S. Comyn, G. Calabrese, M. Taipale, B. Raught, T. Mayor

The paper identifies cytosolic mutant proteins degraded by the proteasome and shows DNAJA2 stabilizes some mutants while being dispensable for wild-type proteins.

bioRxiv · Feb 15, 2024Cell Biology

Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae

G. Strawn, R. Wong, B. Young, M. Davey, C. Nislow, E. Conibear, C. Loewen, T. Mayor

The paper screens yeast mutants to identify genes that enhance recombinant laccase secretion, finding that vesicle trafficking and chaperone proteins are critical for improved protein production.

bioRxiv · Jul 10, 2023 · PreprintMicrobiology

Shift of the insoluble content of the proteome in aging mouse brain

C. M. Molzahn, E. R. Kuechler, I. Zemlyankina, L. Nieves, T. Ali, G. Cole, J. Wang, R. F. Albu, M. Zhu, N. Cashman, S. Gilch, A. Karsan, P. F. Lange, J. Gsponer, T. Mayor

This study identifies age-related changes in the insoluble proteome of mouse brains, showing a shift in protein characteristics associated with proteostasis decline.

bioRxiv · Dec 13, 2022Cell Biology

Pulse labeling reveals the tail end of protein folding by proteome profiling

M. Zhu, E. R. Kuechler, N. Stoynov, J. Gsponer, T. Mayor

The paper identifies newly translated proteins that require more time to fold by analyzing their thermostability under heat stress using pulse SILAC and mass spectrometry.

bioRxiv · Mar 28, 2021Cell Biology

Proteomic analysis reveals the recruitment of intrinsically disordered regions to stress granules

M. Zhu, E. R. Kuechler, J. Zhang, O. Matalon, B. Dubreuil, A. Hofmann, C. J. R. Loewen, E. Levy, J. Gsponer, T. Mayor

The paper identifies heat-regulated yeast proteins that localize to stress granules, showing intrinsically disordered regions (IDRs) are sufficient for SG recruitment and play a critical role in heat-stress response.

bioRxiv · Sep 5, 2019Cell Biology

Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA splicing factors during adipogenesis

Y. Mugabo, M. Sadeghi, N. N. Fang, T. Mayor, G. Lim

The paper identifies novel adipogenic factors and RNA splicing regulators in the 14-3-3ζ interactome, showing their roles in adipocyte differentiation and alternative splicing.

bioRxiv · Sep 5, 2017Physiology