L. Palanikumar

pH-responsive upconversion mesoporous silica nanospheres for combined multimodal diagnostic imaging and targeted photodynamic and photothermal cancer therapy

This paper develops ATRAM-functionalized upconversion mesoporous silica nanospheres for multimodal imaging and combined photodynamic/photothermal cancer therapy, showing effective tumor targeting and treatment with minimal toxicity.

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

This study identifies a small-molecule amyloid inhibitor that disrupts mutant p53 aggregation, restores its function, and reduces tumor growth in xenograft models.