Author

Z. Falls

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

R. Samudrala· 2 shared A. D. Hamilton· 1 shared A. J. Afzal· 1 shared A. J. Frontier· 1 shared A. J. MacRae· 1 shared C. F. Feeney· 1 shared C. L. Kielkopf· 1 shared D. Maity· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

R. Samudrala

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

R. Chatrikhi, C. F. Feeney, M. J. Pulvino, G. Alachouzos, A. J. MacRae, Z. Falls, S. Rai, W. W. Brennessel, J. L. Jenkins, M. J. Walter, T. A. Graubert, R. Samudrala, M. S. Jurica, A. J. Frontier, C. L. Kielkopf

The paper identifies a small molecule that inhibits pre-mRNA splicing by stabilizing an early-stage U2AF2-RNA complex, offering a new strategy for targeting spliceosome assembly.

bioRxiv · Sep 28, 2020Biochemistry

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

L. Palanikumar, L. Karpauskaite, S. Hassan, M. Alam, M. Al-Sayegh, I. Chehade, D. Maity, L. Ali, Z. Falls, R. Samudrala, M. Kalmouni, Y. Hunashal, J. Ahmed, S. Karapetyan, R. Pasricha, , M. Magzoub

This study identifies a small-molecule amyloid inhibitor that disrupts mutant p53 aggregation, restores its function, and reduces tumor growth in xenograft models.

bioRxiv · Aug 10, 2020Cancer Biology