Ferroptosis Regulation by the NGLY1/NFE2L1 Pathway
G. C. Forcina, L. Pope, M. Murray, W. Dong, M. Abu-Remaileh, C. R. Bertozzi, S. J. Dixon
This study identifies the NGLY1/NFE2L1 pathway as a regulator of ferroptosis, showing that NGLY1-mediated deglycosylation of NFE2L1 is necessary for its anti-ferroptotic function through GPX4 expression.
bioRxiv · Oct 12, 2021Cell Biology