Author

L. R. Hurst

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

R. A. Fratti· 3 shared C. Zhang· 2 shared D. A. Rivera-Kohr· 2 shared M. L. Starr· 2 shared A. Arango· 1 shared A. Balutowski· 1 shared A. Guo· 1 shared Aaran VijayakumaraniD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

R. A. Fratti

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Author profile →

4 papers

Recent·Most cited

3D nanoscale architecture of the respiratory epithelium reveals motile cilia-rootlets-mitochondria axis of communication

Aaran Vijayakumaran, Christopher Godbehere, Analle Abuammar, Sophia Y. Breusegem, L. R. Hurst, Nobuhiro Morone, Jaime Llodrá, Melis T. Dalbay, Niaj Mohammad Tanvir, Ajeian Jila, Kirsty MacLellan‐Gibson, Christopher O’Callaghan, Esben Lorentzen, Wei Qiu, Christopher K. E. Bleck, , Vito Mennella

This study reveals a communication axis between motile cilia, rootlets, and mitochondria in respiratory epithelium, enhancing ciliary motility and ATP production.

Cell Reports · Jul 1, 2026Peer-reviewedCell Biology

Sphingolipids regulate the tethering stage of vacuole fusion by affecting membrane fluidity

C. Zhang, L. R. Hurst, Z. D. Gokbayrak, J. D. Calderin, M. R. Hrabak, A. Balutowski, D. A. Rivera-Kohr, T. D. D. Kazmirchuk, C. L. Brett, R. A. Fratti

This study shows that sphingolipids with very long-chain fatty acids regulate vacuole fusion by affecting membrane fluidity and Ypt7 function in yeast.

bioRxiv · Feb 17, 2020 · PreprintCell Biology

Copper Blocks V-ATPase Activity and SNARE Complex Formation to Inhibit Yeast Vacuole Fusion

G. E. Miner, K. D. Sullivan, C. Zhang, L. R. Hurst, M. L. Starr, D. A. Rivera-Kohr, B. C. Jones, A. Guo, R. A. Fratti

This study shows that copper inhibits yeast vacuole fusion by blocking SNARE complex formation and V-ATPase activity, with Cu2+ being the active species.

bioRxiv · May 2, 2019Biochemistry

Phosphatidic acid inhibits SNARE priming by inducing conformational changes in Sec18 protomers

M. L. Starr, R. A. Sparks, L. R. Hurst, Z. Zhao, A. Arango, M. Lihan, J. L. Jenkins, E. Tajkhorshid, R. A. Fratti

This study shows phosphatidic acid (PA) inhibits SNARE priming by altering Sec18 conformation and stabilizing membrane-bound protomers.

bioRxiv · Jul 9, 2018Biochemistry