BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling
L. Shaashua, M. Pevsner-Fischer, G. Friedman, O. Levi-Galibov, S. Nandakumar, R. Nevo, L. E. Brown, W. Zhang, Y. Stein, H. S. Kim, L. Bojmar, W. R. Jarnagin, N. Lecomte, R. Stok, H. Bishara, , R. Scherz-Shouval
This study shows BRCA mutations in pancreatic cancer alter CAF subtypes, specifically increasing CLU+ CAFs, and links this to HSF1 signaling.
bioRxiv · Aug 18, 2021 · PreprintCancer Biology