Author

L. T. Vo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Kimberlin· 1 shared A. Marson· 1 shared A. Seth· 1 shared A. Wozniak· 1 shared C. Jeans· 1 shared D. F. Savage· 1 shared D. Goodman· 1 shared D. N. Nguyen· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

A. Kimberlin

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2 papers

Recent·Most cited

Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs

E. C. Stahl, J. K. Sabo, M. H. Kang, R. Allen, E. Applegate, S. E. Kim, Y. Kwon, A. Seth, N. Lemus, V. Salinas-Rios, K. Soczek, M. Trinidad, L. T. Vo, C. Jeans, A. Wozniak, , J. A. Doudna

This study demonstrates that minimally immunogenic Cas9 RNPs delivered via convection enhanced delivery can edit mouse striatal neurons with reduced immune responses compared to AAV-delivered Cas9.

bioRxiv · Apr 13, 2023Bioengineering

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances genome targeting in diverse human immune cell types

D. N. Nguyen, T. L. Roth, J. Li, P. A. Chen, M. M. Mamedov, L. T. Vo, V. Tobin, R. Apathy, D. Goodman, E. Shifrut, J. A. Bluestone, J. M. Puck, F. C. Szoka, A. Marson

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.

bioRxiv · Mar 28, 2019 · PreprintBioengineering