D. N. Nguyen

Regulation of host metabolism and defense strategies to survive neonatal infection

This study compares metabolic and defense strategies in preterm piglets infected with S. epidermidis, finding that survivors exhibit early resistance and later tolerance, linked to mitochondrial metabolism and improved survival.

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

This study shows that reducing glucose supply during infection improves survival in preterm infants by decreasing inflammation and maintaining normoglycemia, with liver involvement in these protective effects.

Insulin-like Growth Factor-1 Supplementation Promotes Kidney Development and Alleviate Renal Inflammation in Preterm Pigs

This study shows that IGF-1 supplementation improves kidney development and reduces inflammation in preterm pigs.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

Parenteral glucose supply and pharmacological glycolysis inhibition determine the clinical fate of infected preterm newborns

This study shows that high parenteral glucose during infection in preterm infants leads to sepsis, while glucose restriction prevents it, highlighting the role of glucose in immune response.

Necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs

This study shows that necrotizing enterocolitis (NEC) in preterm pigs leads to systemic immune suppression, increasing susceptibility to secondary infections.

Fecal filtrate transfer protects against necrotizing enterocolitis in preterm pigs

This study shows that fecal filtrate transfer prevents necrotizing enterocolitis in preterm pigs without side effects, while fecal microbiota transplantation does not.

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances genome targeting in diverse human immune cell types

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.