Author

R. Apathy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Marson· 3 shared E. Shifrut· 3 shared T. L. Roth· 3 shared D. Goodman· 2 shared D. N. Nguyen· 2 shared J. A. Bluestone· 2 shared R. Yu· 2 shared A. To· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

A. Marson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

F. Blaeschke, Y. Y. Chen, R. Apathy, Z. Li, C. T. Mowery, W. A. Nyberg, A. To, R. Yu, R. Bueno, M. C. Kim, R. Schmidt, D. B. Goodman, T. Feuchtinger, J. Eyquem, C. J. Ye, , A. Marson

The paper develops ModPoKI, a platform for modular construction of DNA knockin libraries to identify gene constructs that enhance T cell function and persistence.

bioRxiv · Jul 27, 2022Immunology

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

T. L. Roth, P. J. Li, J. Nies, R. Yu, M. L. T. Nguyen, Y. Lee, R. Apathy, A. Truong, J. Hiatt, D. Wu, D. N. Nguyen, D. Goodman, J. A. Bluestone, K. Roybal, E. Shifrut, A. Marson

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.

bioRxiv · Apr 12, 2019 · PreprintImmunology

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances genome targeting in diverse human immune cell types

D. N. Nguyen, T. L. Roth, J. Li, P. A. Chen, M. M. Mamedov, L. T. Vo, V. Tobin, R. Apathy, D. Goodman, E. Shifrut, J. A. Bluestone, J. M. Puck, F. C. Szoka, A. Marson

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.

bioRxiv · Mar 28, 2019 · PreprintBioengineering