Author

L. Valencia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. Cabrera Paz· 3 shared L. Marnin· 3 shared L. R. Butler· 3 shared N. Singh· 3 shared A. Oliva Chavez· 2 shared A. Rolandelli· 2 shared D. Serre· 2 shared H. Bogale· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

F. Cabrera Paz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tick extracellular vesicles alter keratinocyte function in the skin epidermis

L. Marnin, L. Valencia, H. Bogale, H. Laukaitis-Yousey, A. Rolandelli, C. R. Ferraz, A. J. O'Neal, A. Schmitter-Sanchez, E. Bencosme Cuevas, T.-T. Nguyen, B. Leal-Galvan, D. M. Rickert, M. T. Mendes, S. Samaddar, L. R. Butler, , J. H. F. Pedra

This study shows that tick extracellular vesicles alter keratinocyte function in the epidermis by inhibiting proliferation and wound closure, linked to phosphoinositide 3-kinase, KGF-1, and TGF-β.

bioRxiv · Nov 10, 2023 · PreprintMicrobiology

Rab27 in tick extracellular vesicle biogenesis and infection

L. R. Butler, N. Singh, L. Marnin, L. Valencia, A. O'Neal, F. Cabrera Paz, D. K. Shaw, A. Oliva Chavez, J. Pedra

This study identifies Rab27 as essential for tick extracellular vesicle biogenesis and its role in bacterial acquisition during feeding.

bioRxiv · Nov 2, 2023 · PreprintMicrobiology

Tick hemocytes have pleiotropic roles in microbial infection and arthropod fitness

A. Rolandelli, H. Laukaitis-Yousey, H. Bogale, N. Singh, S. Samaddar, A. ONeal, C. Ferraz, M. Butnaru, E. Mameli, B. Xia, M. T. Mendes, L. R. Butler, L. Marnin, F. Cabrera Paz, L. Valencia, , J. Pedra

This study identifies hemocyte heterogeneity and pleiotropic roles in ticks using multi-omics approaches, revealing their impact on immunity, metabolism, and arthropod fitness.

bioRxiv · Aug 31, 2023 · PreprintImmunology

The AMIGO1 adhesion protein activates Kv2.1 voltage sensors

R. J. Sepela, R. G. Stewart, L. Valencia, P. Thapa, Z. Wang, B. E. Cohen, J. T. Sack

This study identifies how AMIGO1 modulates Kv2.1 voltage sensor movements and conductance activation by destabilizing the earliest resting state.

bioRxiv · Jun 20, 2021Biophysics

Chemoinformatic-guided engineering of polyketide synthases

A. Zargar, R. Lal, L. Valencia, J. Wang, T. Backman, P. Cruz-Morales, A. Kothari, M. Werts, A. Wong, C. B. Bailey, A. Loubat, Y. Liu, Y. Chen, V. Benites, S. Chang, , J. D. Keasling

This study uses chemoinformatics to engineer polyketide synthases for producing saturated β-carbon compounds, finding a correlation between chemical similarity and product titers.

bioRxiv · May 10, 2020Biochemistry