Author

T.-T. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 5 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1

Frequent Co-Authors

M. V. Hull· 2 shared A. Chatterjee· 1 shared A. Garcia-Sastre· 1 shared A. I. Su· 1 shared A. J. O'Neal· 1 shared A. Matthaei· 1 shared A. Mulenga· 1 shared A. Oliva Chavez· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

M. V. Hull

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Tick extracellular vesicles alter keratinocyte function in the skin epidermis

L. Marnin, L. Valencia, H. Bogale, H. Laukaitis-Yousey, A. Rolandelli, C. R. Ferraz, A. J. O'Neal, A. Schmitter-Sanchez, E. Bencosme Cuevas, T.-T. Nguyen, B. Leal-Galvan, D. M. Rickert, M. T. Mendes, S. Samaddar, L. R. Butler, , J. H. F. Pedra

This study shows that tick extracellular vesicles alter keratinocyte function in the epidermis by inhibiting proliferation and wound closure, linked to phosphoinositide 3-kinase, KGF-1, and TGF-β.

bioRxiv · Nov 10, 2023 · PreprintMicrobiology

Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 Entry

S. Jablonski, H. Mou, Y. Otsuka, J. Jablonski, R. S. Adcock, L. Batra, D. Chung, C. Rood, I. M. de Vera, R. Rahaim, S. Ullah, X. Yu, T.-T. Nguyen, M. V. Hull, E. Chen, , T. Spicer

This study identifies small molecule inhibitors of SARS-CoV-2 entry through high-throughput screening and validates Calpeptin as a potent inhibitor of SARS-CoV-2 and some variants.

bioRxiv · Aug 5, 2021Microbiology

Repurposing screen highlights broad-spectrum coronavirus antivirals and their host targets

S. Haid, A. Matthaei, M. Winkler, S. M. Sake, A. P. Gunesch, J. Rueckert, G. Vieyres, D. Kuehl, T.-T. Nguyen, L. Lasswitz, F. Zapatero, G. Brogden, G. Gerold, B. Wiegmann, U. Bilitewski, , T. Pietschmann

The paper screens a drug library to identify broad-spectrum coronavirus antivirals and their host targets, finding compounds that inhibit both alpha- and beta-coronaviruses.

bioRxiv · Jul 14, 2021 · PreprintMicrobiology

Combination of in vivo phage therapy data with in silico model highlights key parameters for treatment efficacy

R. Delattre, J. Seurat, F. Haddad, T.-T. Nguyen, B. Gaborieau, R. Kane, N. Dufour, J.-D. Ricard, J. Guedj, L. Debarbieux

The paper combines in vivo phage therapy data with an in silico model to identify key parameters affecting treatment efficacy in bacterial pneumonia.

bioRxiv · Mar 4, 2021Microbiology

High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.

R. Choi, M. Zhou, R. Shek, J. W. Wilson, L. Tillery, J. K. Craig, I. A. Salukhe, S. E. Hickson, N. Kumar, R. M. James, G. W. Buchko, R. Wu, S. Huff, T.-T. Nguyen, B. L. Hurst, , W. C. Van Voorhis

The paper screens drug libraries to find inhibitors of SARS-CoV-2 nsp15 endoribonuclease, identifying Exebryl-1 as a potential antiviral compound.

bioRxiv · Jan 21, 2021Microbiology

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

L. Riva, S. Yuan, X. Yin, L. Martin-Sancho, N. Matsunaga, S. Burgstaller, L. Pache, P. De Jesus, M. V. Hull, M. Chang, J. F. W. Chan, J. Cao, V. Kwok-Man Poon, K. Herbert, T.-T. Nguyen, , S. Chanda

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

bioRxiv · Apr 16, 2020 · PreprintMicrobiology