L. Zeng

This study shows that evolutionary arms race between bat SARSr-CoV spike proteins and ACE2 drives genetic diversity, with SARSr-CoV spike proteins showing higher binding affinity to human ACE2 than bat ACE2.

This study identifies CVB3 VP1 as an inhibitor of cell proliferation by disrupting MAT1 interaction with the CAK complex, thereby blocking CAK-CDK4/6-Rb signaling in pancreatic cells.

The paper identifies mutanofactin-697, a secondary metabolite from S. mutans, which promotes biofilm formation by increasing bacterial hydrophobicity and adhesion.

This study shows that enhanced RNA-directed DNA methylation (RdDM) in reproductive organs increases DNA methylation, ensuring sexual reproduction in rice by regulating gene expression.

This study shows PLCγ1 promotes phase separation of LAT in T cell signaling by crosslinking it and protecting it from dephosphorylation, enhancing ERK and SLP76 activation.

This study investigates how amino sugars like GlcN and GlcNAc affect gene expression and interactions between Streptococcus mutans and Streptococcus gordonii, revealing significant transcriptomic changes and metabolic reprogramming.

This paper develops a CRISPR-Cas13-based strategy called PAC-MAN to inhibit SARS-CoV-2 and influenza A virus in human cells, showing it can degrade viral sequences and reduce replication.

The paper shows MEcPP coordinates auxin and ethylene signaling via phytochrome B to regulate hypocotyl growth in response to light.

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

The paper develops a biosensor platform called SPAR for rapid and sensitive pathogen detection using engineered cells and antibodies.

This study shows amino sugars like GlcNAc and GlcN enhance the competitiveness of commensal oral streptococci against S. mutans, reducing its viability in co-cultures and biofilms.

This paper identifies the sppRA operon in Streptococcus mutans, showing it regulates fructose metabolism and virulence by modulating fructose-1-phosphate levels and stress responses.

This study shows that Streptococcus mutans exhibits long-term memory effects in lactose catabolism based on prior exposure to glucose or fructose, with implications for bacterial persistence and virulence.

This study investigates the impact of transposable elements (TEs) on gene expression across six amniote species, finding species-specific associations and unexpected patterns in expression changes.