Author

B. S. Tolbert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. E. Hargrove· 3 shared G. Brewer· 2 shared J. Davila-Calderon· 2 shared L.-Y. Chiu· 2 shared M.-L. Li· 2 shared Z. Cai· 2 shared A. A. Kennedy· 1 shared A. Donlic· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

A. E. Hargrove

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Thermodynamic Coupling of the tandem RRM domains of hnRNP A1 underlie its Pleiotropic RNA Binding Functions

J. D. Levengood, D. Potoyan, S. Penumutchu, A. Kumar, Y. Wang, A. L. Hansen, S. Kutluay, J. Roche, B. S. Tolbert

This study shows that thermodynamic coupling between tandem RRM domains of hnRNP A1 is essential for its allosteric RNA binding functions and stability under pressure.

bioRxiv · Aug 17, 2023 · PreprintBiochemistry

R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures

A. Donlic, E. G. Swanson, L.-Y. Chiu, S. L. Wicks, A. Umuhire Juru, Z. Cai, K. J. Kassam, C. Laudeman, B. Sanaba, A. Sugarman, E. Han, B. S. Tolbert, A. E. Hargrove

R-BIND 2.0 updates the database of RNA-targeting small molecules by refining curation, analyzing RNA structures, and introducing a search algorithm for structure-based ligand discovery.

bioRxiv · Mar 14, 2022Biochemistry

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

M. Zafferani, C. Haddad, L. Luo, J. Davila-Calderon, L. Yuan-Chiu, C. Shema Mugisha, A. G. Monaghan, A. A. Kennedy, J. D. Yesselman, R. R. Gifford, A. W. Tai, S. B. Kutluay, M.-L. Li, G. Brewer, B. S. Tolbert, A. E. Hargrove

This study identifies amilorides as small molecules that inhibit SARS-CoV-2 replication by targeting conserved RNA structures in the 5-UTR region.

bioRxiv · Dec 5, 2020Microbiology

Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex

J. Davila-Calderon, N. N. Patwardhan, L.-Y. Chiu, A. L. Sugarman, Z. Cai, S. R. Penutmutchu, M.-L. Li, G. Brewer, A. E. Hargrove, B. S. Tolbert

The paper identifies a small molecule that inhibits EV71 replication by stabilizing a ternary complex with RNA and AUF1 protein via an allosteric mechanism.

bioRxiv · Mar 10, 2020Biochemistry