A. E. Hargrove

Probing Bioactive Chemical Space to Discover RNA-Targeted Small Molecules

The paper curates a large RNA-targeted small molecule library and identifies novel RNA-binding compounds through in vitro assays.

R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures

R-BIND 2.0 updates the database of RNA-targeting small molecules by refining curation, analyzing RNA structures, and introducing a search algorithm for structure-based ligand discovery.

RT-qPCR as a screening platform for mutational and small molecule impacts on structural stability of RNA tertiary structures

The paper develops a high-throughput RT-qPCR platform to assess how mutations and small molecules affect RNA triple helix stability, using MALAT1 as a model.

Structural analysis of the lncRNA SChLAP1 reveals protein binding interfaces and a conformationally heterogenous retroviral insertion

This study presents the first secondary structure model of SChLAP1, identifies protein binding sites, and reveals a retroviral insertion contributing to its structural complexity and potential role in prostate cancer.

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

This study identifies amilorides as small molecules that inhibit SARS-CoV-2 replication by targeting conserved RNA structures in the 5-UTR region.

Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex

The paper identifies a small molecule that inhibits EV71 replication by stabilizing a ternary complex with RNA and AUF1 protein via an allosteric mechanism.