Author

G. Brewer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:phylogenetics / evolution· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. E. Hargrove· 2 shared B. S. Tolbert· 2 shared J. Davila-Calderon· 2 shared M.-L. Li· 2 shared A. A. Kennedy· 1 shared A. Barker· 1 shared A. G. Monaghan· 1 shared A. L. Sugarman· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMicrobiology

A. E. Hargrove

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Comprehensive Phylogenomic Platform for Exploring the Angiosperm Tree of Life

W. J. Baker, P. Bailey, V. Barber, A. Barker, S. Bellot, D. Bishop, L. R. Botigue, G. Brewer, T. Carruthers, J. J. Clarkson, J. Cook, R. S. Cowan, S. Dodsworth, N. Epitawalage, E. Francoso, , F. Forest

This paper introduces a phylogenomic platform for angiosperms, providing a large dataset and open tool for exploring the flowering plant tree of life.

bioRxiv · Feb 22, 2021Evolutionary Biology

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

M. Zafferani, C. Haddad, L. Luo, J. Davila-Calderon, L. Yuan-Chiu, C. Shema Mugisha, A. G. Monaghan, A. A. Kennedy, J. D. Yesselman, R. R. Gifford, A. W. Tai, S. B. Kutluay, M.-L. Li, G. Brewer, B. S. Tolbert, A. E. Hargrove

This study identifies amilorides as small molecules that inhibit SARS-CoV-2 replication by targeting conserved RNA structures in the 5-UTR region.

bioRxiv · Dec 5, 2020Microbiology

Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex

J. Davila-Calderon, N. N. Patwardhan, L.-Y. Chiu, A. L. Sugarman, Z. Cai, S. R. Penutmutchu, M.-L. Li, G. Brewer, A. E. Hargrove, B. S. Tolbert

The paper identifies a small molecule that inhibits EV71 replication by stabilizing a ternary complex with RNA and AUF1 protein via an allosteric mechanism.

bioRxiv · Mar 10, 2020Biochemistry