Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer
Emira J. Visser, Maria Donaldson Collier, Joseph C. Siefert, Markella Konstantinidou, Susana N. Paul, Jari B. Berkhout, Johanna M. Virta, Bente A. Somsen, Peter J. Cossar, Galen P. Miley, Lara Luzietti, Leonie S. Young, Damir Varešlija, Laki Buluwela, Simak Ali, , Luc Brunsveld
This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.
bioRxiv · Apr 25, 2024 · PreprintCancer Biology