Author

Jari B. Berkhout

Leiden University Medical CenterORCID 0000-0002-0776-6995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Onno Cornelis MeijeriD· 3 shared Ahmed Essam MahfouziD· 2 shared Andries KalsbeekiD· 1 shared Bente A. SomseniD· 1 shared Christian OttmanniD· 1 shared Chun‐Xia YiiD· 1 shared Damir VarešlijaiD· 1 shared Delaram PoormoghadamiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Onno Cornelis MeijerORCID

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Author profile →

3 papers

Recent·Most cited

FOXP1 differentially regulates the development of murine vasopressin and oxytocin magnocellular neurons

Jari B. Berkhout, Sophie Trender, Quirin Krabichler, Yuval Podpecan, Felix Franke, Tim Schubert, J. Peter H. Burbach, Valery Grinevich, Roger A.H. Adan, Henning Fröhlich, Ferdinand Althammer, Onno Cornelis Meijer, Ahmed Essam Mahfouz

The paper identifies FOXP1 as a key regulator of oxytocin neuron differentiation and shows its role in reducing AVP and OXT neuron abundance in knockout mice.

iScience · Apr 4, 2026Peer-reviewedNeuroscience

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

Emira J. Visser, Maria Donaldson Collier, Joseph C. Siefert, Markella Konstantinidou, Susana N. Paul, Jari B. Berkhout, Johanna M. Virta, Bente A. Somsen, Peter J. Cossar, Galen P. Miley, Lara Luzietti, Leonie S. Young, Damir Varešlija, Laki Buluwela, Simak Ali, , Luc Brunsveld

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

bioRxiv · Apr 25, 2024 · PreprintCancer Biology

An integrated single-cell RNA-seq atlas of the mouse hypothalamic paraventricular nucleus links transcriptional and functional types

Jari B. Berkhout, Delaram Poormoghadam, Chun‐Xia Yi, Andries Kalsbeek, Onno Cornelis Meijer, Ahmed Essam Mahfouz

This study creates a detailed single-cell RNA-seq atlas of the mouse PVN, identifying transcriptional subtypes and linking them to functional roles.

Journal of Neuroendocrinology · Jan 28, 2024Peer-reviewedNeuroscience