Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging
Chloe Lopez-Lee, Lay Kodama, Li Fan, Man Ying Wong, Nessa R. Foxe, Laraib Jiaz, Fangmin Yu, Pearly Ye, Jingjie Zhu, Kendra Norman, Eileen Ruth S. Torres, Rachel D. Kim, Gergey Alzaem Mousa, Dena B. Dubal, Shane Antony Liddelow, , Li Gan
The paper identifies sex-biased transcriptomic responses in aged demyelination, showing Tlr7 mediates these differences through interactions with sex chromosomes and gonads.
bioRxiv · Sep 19, 2023 · PreprintNeuroscience