Author

Eileen Ruth S. Torres

Weill Cornell MedicineORCID 0000-0002-5340-8734Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

Jingjie ZhuiD· 4 shared Li FaniD· 4 shared Pearly Ye· 4 shared Daphne Zhu· 3 shared Kendra Norman· 3 shared Li GaniD· 3 shared Man Ying WongiD· 3 shared Nessa R. Foxe· 3 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Jingjie ZhuORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity

Caitlin Castagnola, Roberta Marongiu, Yuansong Wan, Eileen Ruth Torres, Li Fan, Minwoo Wendy Jang, Qiaoling Cui, Jihye Kim, Pearly Ye, Jingjie Zhu, Alisa Panichkina, Alexandra B. Fall, Kendra Norman, Beichen Gao, Nessa R. Foxe, , Li Gan

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

bioRxiv · May 7, 2026 · PreprintNeuroscience

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention

Sabina Marciano, Leandra G. Velazquez, Claudia Rodríguez López, Neranjan de Silva, Garrett Sommer, William Tower, Eileen Ruth S. Torres, Michael G. Kaplitt, Teresa A. Milner, Roberta Marongiu

This paper develops an optimized AAV.TH.SNCA model to study early α-synuclein pathology in mice, showing that motor deficits and neurochemical changes occur before neuronal loss.

bioRxiv · Apr 30, 2026 · PreprintNeuroscience

Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity

Bangyan Liu, Matthew Mahoney, Yilin Feng, Maria A. Telpoukhovskaia, Alice Maria Giani, Eileen Ruth Torres, Lihong Zhan, Pearly Ye, Jingjie Zhu, Nessa R. Foxe, Daphne Zhu, Xinran Tong, Deepak Srivastava, Christina V. Theodoris, Shiaoching Gong, , Li Gan

This study identifies soluble DLK1 from senescent microglia as a factor impairing oligodendrocyte function and altering neuronal activity in aging.

bioRxiv · Jan 15, 2026 · PreprintNeuroscience

APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition

Sarah A. Naguib, Chloe Lopez-Lee, Eileen Ruth S. Torres, Se-In Lee, Jingjie Zhu, Daphne Zhu, Pearly Ye, Kendra Norman, Mingrui Zhao, Man Ying Wong, Yohannes A. Ambaw, Rodrigo Castaneda, Wei Wang, Tark Patel, Maitreyee Bhagwat, , Li Gan

The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.

bioRxiv · Apr 25, 2024 · PreprintNeuroscience

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging

Chloe Lopez-Lee, Lay Kodama, Li Fan, Man Ying Wong, Nessa R. Foxe, Laraib Jiaz, Fangmin Yu, Pearly Ye, Jingjie Zhu, Kendra Norman, Eileen Ruth S. Torres, Rachel D. Kim, Gergey Alzaem Mousa, Dena B. Dubal, Shane Antony Liddelow, , Li Gan

The paper identifies sex-biased transcriptomic responses in aged demyelination, showing Tlr7 mediates these differences through interactions with sex chromosomes and gonads.

bioRxiv · Sep 19, 2023 · PreprintNeuroscience