Author

Nessa R. Foxe

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Li FaniD· 5 shared Jingjie ZhuiD· 4 shared Li GaniD· 4 shared Man Ying WongiD· 4 shared Pearly Ye· 4 shared Shiaoching GongiD· 4 shared Chloe Lopez-LeeiD· 3 shared Daphne Zhu· 3 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Li FanORCID

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5 papers

Recent·Most cited

Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity

Caitlin Castagnola, Roberta Marongiu, Yuansong Wan, Eileen Ruth Torres, Li Fan, Minwoo Wendy Jang, Qiaoling Cui, Jihye Kim, Pearly Ye, Jingjie Zhu, Alisa Panichkina, Alexandra B. Fall, Kendra Norman, Beichen Gao, Nessa R. Foxe, , Li Gan

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

bioRxiv · May 7, 2026 · PreprintNeuroscience

Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity

Bangyan Liu, Matthew Mahoney, Yilin Feng, Maria A. Telpoukhovskaia, Alice Maria Giani, Eileen Ruth Torres, Lihong Zhan, Pearly Ye, Jingjie Zhu, Nessa R. Foxe, Daphne Zhu, Xinran Tong, Deepak Srivastava, Christina V. Theodoris, Shiaoching Gong, , Li Gan

This study identifies soluble DLK1 from senescent microglia as a factor impairing oligodendrocyte function and altering neuronal activity in aging.

bioRxiv · Jan 15, 2026 · PreprintNeuroscience

DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Jingjie Zhu, Nessa R. Foxe, Winston T. Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue‐Ann Mok, , Wenjie Luo

This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.

Molecular Neurodegeneration · Dec 2, 2025Peer-reviewedNeuroscience

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Gillian Carling, Li Fan, Nessa R. Foxe, Kendra Norman, Man Ying Wong, Daphne Zhu, Carlo Corona, Agnese Razzoli, Fangmin Yu, Allan Yarahmady, Pearly Ye, Hao Chen, Yige Huang, Sadaf Amin, Rebecca Sereda, , Li Gan

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

Neuron · Sep 30, 2024Peer-reviewedNeuroscience

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging

Chloe Lopez-Lee, Lay Kodama, Li Fan, Man Ying Wong, Nessa R. Foxe, Laraib Jiaz, Fangmin Yu, Pearly Ye, Jingjie Zhu, Kendra Norman, Eileen Ruth S. Torres, Rachel D. Kim, Gergey Alzaem Mousa, Dena B. Dubal, Shane Antony Liddelow, , Li Gan

The paper identifies sex-biased transcriptomic responses in aged demyelination, showing Tlr7 mediates these differences through interactions with sex chromosomes and gonads.

bioRxiv · Sep 19, 2023 · PreprintNeuroscience