Author

Chloe Lopez-Lee

Weill Cornell MedicineORCID 0000-0002-1013-3005Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Li FaniD· 4 shared Li GaniD· 4 shared Man Ying WongiD· 4 shared Wenjie LuoiD· 4 shared Jingjie ZhuiD· 3 shared Kendra Norman· 3 shared Nessa R. Foxe· 3 shared Pearly Ye· 3 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Li FanORCID

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Author profile →

4 papers

Recent·Most cited

DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Jingjie Zhu, Nessa R. Foxe, Winston T. Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue‐Ann Mok, , Wenjie Luo

This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.

Molecular Neurodegeneration · Dec 2, 2025Peer-reviewedNeuroscience

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Gillian Carling, Li Fan, Nessa R. Foxe, Kendra Norman, Man Ying Wong, Daphne Zhu, Carlo Corona, Agnese Razzoli, Fangmin Yu, Allan Yarahmady, Pearly Ye, Hao Chen, Yige Huang, Sadaf Amin, Rebecca Sereda, , Li Gan

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

Neuron · Sep 30, 2024Peer-reviewedNeuroscience

APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition

Sarah A. Naguib, Chloe Lopez-Lee, Eileen Ruth S. Torres, Se-In Lee, Jingjie Zhu, Daphne Zhu, Pearly Ye, Kendra Norman, Mingrui Zhao, Man Ying Wong, Yohannes A. Ambaw, Rodrigo Castaneda, Wei Wang, Tark Patel, Maitreyee Bhagwat, , Li Gan

The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.

bioRxiv · Apr 25, 2024 · PreprintNeuroscience

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging

Chloe Lopez-Lee, Lay Kodama, Li Fan, Man Ying Wong, Nessa R. Foxe, Laraib Jiaz, Fangmin Yu, Pearly Ye, Jingjie Zhu, Kendra Norman, Eileen Ruth S. Torres, Rachel D. Kim, Gergey Alzaem Mousa, Dena B. Dubal, Shane Antony Liddelow, , Li Gan

The paper identifies sex-biased transcriptomic responses in aged demyelination, showing Tlr7 mediates these differences through interactions with sex chromosomes and gonads.

bioRxiv · Sep 19, 2023 · PreprintNeuroscience