TSP1/TGF-β1 drives arachidonic acid metabolism to orchestrate neutrophil swarming
Lars Widera, Philippa Spangenberg, Devon Siemes, Sebastian Bessler, Jenny Bottek, Hannah Voß, Angelo Novak, Darleen Hueser, Mathis Richter, Alexander Potthoff, Bente Siebels, Manuela Moritz, Antonia Gocke, Stephanie Thiebes, Stephanie Tautges, , Daniel Robert Engel
The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.
bioRxiv · Nov 25, 2025 · PreprintImmunology