Author

Sebastian Bessler

University of MünsterORCID 0000-0002-0377-1164Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:imaging· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Jens SoltwischiD· 4 shared Klaus DreisewerdiD· 4 shared Oliver SoehnleiniD· 4 shared Mathis RichteriD· 3 shared Alexander PotthoffiD· 2 shared Daniel Robert EngeliD· 2 shared Devon SiemesiD· 2 shared Jan SchwenzfeieriD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersImmunology

Jens SoltwischORCID

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4 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 25, 2025

TSP1/TGF-β1 drives arachidonic acid metabolism to orchestrate neutrophil swarming

Lars Widera, Philippa Spangenberg, Devon Siemes…·Daniel Robert Engel

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

DOI 10.1101/2025.11.25.688397

humanproteomics

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Cell BiologyNature CommunicationsPeer-reviewedOct 15, 2025

Histology-Guided Single-Cell Mass Spectrometry Imaging using Integrated Bright-field and Fluorescence Microscopy

Alexander Potthoff, Jan Schwenzfeier, Marcel Niehaus…·Jens Soltwisch

This paper integrates MALDI-MSI with bright-field and fluorescence microscopy to correlate lipid profiles with morphological and protein features at the single-cell level.

46 citationstop 1%

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ImmunologybioRxivPreprintAug 19, 2025

Single-cell mass spectrometry imaging combined with immunofluorescence reveals neutrophil heterogeneity in inflammation

Sebastian Bessler, Mathis Richter, Jan Schwenzfeier…·Oliver Soehnlein

The paper combines single-cell mass spectrometry imaging and immunofluorescence to identify pathogenic neutrophils in liver cirrhosis patients.

2 citations

humanspatial transcriptomics

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BioinformaticsbioRxivPreprintAug 24, 2024

msiFlow: Automated Workflows for Reproducible and Scalable Multimodal Mass Spectrometry Imaging and Immunofluorescence Microscopy Data Processing and Analysis

Philippa Spangenberg, Sebastian Bessler, Lars Widera…·Daniel Robert Engel

msiFlow automates and streamlines multimodal mass spectrometry imaging and immunofluorescence data analysis to enhance reproducibility and scalability in biological research.

1 citation

imagingexperimental assay

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