Glycosylated GM-CSF expands B-1b cells and B-1b plasma cells and programs them for immunosuppression
Haisam Alattar, Arpa Aintablian, I Eckert, Haroon Shaikh, Laura Cyran, Zheng Liu, Bhupesh Kumar Prusty, Fabian Imdahl, Elisabeth Zinser, Andreas Beilhack, Nadine Hövelmeyer, Björn E. Clausen, Tom Gräfenhan, Florian Erhard, Manfred Bernhard Lutz
This study shows glycosylated GM-CSF expands immunosuppressive B-1b plasma cells and promotes regulatory functions, while non-glycosylated GM-CSF drives pro-inflammatory responses.
bioRxiv · Feb 4, 2026 · PreprintImmunology