Nadine Hövelmeyer

OTUB1 controls marginal zone B-cell development by stabilizing RelA in a CD40-dependent manner

This study shows OTUB1 stabilizes RelA by preventing its ubiquitination and degradation, which is crucial for controlling marginal zone B-cell development through CD40-dependent NF-κB signaling.

Prohibitin 2 is a Key Regulator of T Cell Proliferation, Differentiation, and Effector Functions in vivo

This study investigates the role of PHB2 in T cell proliferation, differentiation, and effector functions, finding that PHB2 deficiency causes cell cycle arrest and metabolic dysfunction.

A streamlined spectral cytometry method for FAD and NADH autofluorescence analysis in immunometabolic studies

The paper introduces a streamlined spectral cytometry method to analyze NADH and FAD autofluorescence in immune cells, demonstrating its application in assessing metabolic states of splenic B-cell subsets.

Treg-derived IκBζ promotes their conversion into Th2-like effectors and drives type 2 inflammation via BATF

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8+ T cell response

This study shows B cells sustain Langerin+ cDC1s via LTβ and MMMs to support anti-viral CD8+ T cell responses during MCMV infection.

Glycosylated GM-CSF expands B-1b cells and B-1b plasma cells and programs them for immunosuppression

This study shows glycosylated GM-CSF expands immunosuppressive B-1b plasma cells and promotes regulatory functions, while non-glycosylated GM-CSF drives pro-inflammatory responses.

Aging-Associated Microbiota Drives Treg Dysfunction via TNF Signaling

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.