Author

Laura J Grundy

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

Ewan St. John SmithiD· 2 shared Anne RitouxiD· 1 shared Fangze Tong· 1 shared Filomena GalloiD· 1 shared Janet R. KumitaiD· 1 shared Karin H. MülleriD· 1 shared Larissa FergusoniD· 1 shared Luke W PaineiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Ewan St. John SmithORCID

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2 papers

Recent·Most cited

A live-cell autophagy reporter reveals reversible vacuolation in naked mole-rat skin fibroblasts under lysosomal stress

Fangze Tong, Mateo P. Hoare, Laura J Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita

This study uses a live-cell autophagy reporter to show that naked mole-rat skin fibroblasts form reversible vacuoles under lysosomal stress, indicating dynamic lysosomal remodelling.

FEBS Journal · Aug 14, 2026Peer-reviewedCell Biology

Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables tunable self-amplifying RNA expression with reduced immunotoxicity

Tony K.Y. Lim, Anne Ritoux, Luke W Paine, Larissa Ferguson, Tawab Abdul, Laura J Grundy, Ewan St. John Smith

This paper develops a strategy to reduce immunotoxicity in self-amplifying RNA by encoding immune suppressors that bypass translation shutdown, enabling sustained transgene expression in mouse cells.

eLife · Aug 29, 2025Peer-reviewedBioengineering