Larissa Ferguson

DeorphaNN identifies peptide agonists for GPCRs using AlphaFold structural predictions and deep learning embeddings, successfully uncovering agonists for two orphan receptors across species.

This paper develops a strategy to reduce immunotoxicity in self-amplifying RNA by encoding immune suppressors that bypass translation shutdown, enabling sustained transgene expression in mouse cells.

CysPresso predicts recombinant expression of cysteine-dense peptides using deep learning protein representations, finding AlphaFold2 features most effective for this task.

The paper shows that isoform-specific stabilization of PKMs by KIBRA determines isoform specificity during long-term facilitation in Aplysia.