Tony K.Y. Lim

DeorphaNN identifies peptide agonists for GPCRs using AlphaFold structural predictions and deep learning embeddings, successfully uncovering agonists for two orphan receptors across species.

This paper develops a strategy to reduce immunotoxicity in self-amplifying RNA by encoding immune suppressors that bypass translation shutdown, enabling sustained transgene expression in mouse cells.

This study investigates how inflammatory mediators affect TRPM3 channel function in mouse sensory neurons and finds that IL-1β and TNF potentiate TRPM3 without changing its expression, while pharmacological blockade does not alleviate inflammatory pain in a specific model.

CysPresso predicts recombinant expression of cysteine-dense peptides using deep learning protein representations, finding AlphaFold2 features most effective for this task.

The paper observes microglial trogocytosis of axons in vivo and identifies complement regulatory proteins that modulate this process and axonal pruning.