Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells
Hooman Hefzi, Iván Martínez‐Monge, Igor Marín de Mas, Nicholas Luke Cowie, Alejandro Gómez Toledo, Soo Min Noh, Karen Julie la Cour Karottki, Marianne Decker, Johnny Arnsdorf, Jose Manuel Camacho-Zaragoza, Stefan Kol, Sanne Schoffelen, Nuša Pristovšek, Anders Holmgaard Hansen, Antonio Alarcón Miguez, , Nathan E. Lewis
This study eliminates the Warburg Effect in mammalian cells by knocking out lactate dehydrogenase and feedback regulators, maintaining growth rate while reducing lactate production.
Nature Metabolism · Jan 14, 2025Peer-reviewedBioengineering