PathologybioRxivPreprint
Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis
Qianjiang Hu, Ugochi Onwuka, Nayra Cárdenes…·Mélanie Königshoff
This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.