Anna Lena Jung

Functional Mapping and Engineering of the Sec Translocon Unlocked by a Cell-Free System

The paper presents a cell-free system for studying Sec translocon function, identifies super-active variants, and demonstrates applications in improving membrane protein and nanobody export.

Lifespan Analysis of the Lung Epithelium Reveals Inflammatory Reprogramming and Regenerative Decline

This study analyzes lung epithelial cells across the lifespan in mice, identifying age-related declines in regeneration linked to inflammation and epigenetic changes.

Engineering site-specific nucleic acid-protein conjugates by utilizing a natural RNAylation reaction

This paper establishes RNAylation as a method to create site-specific nucleic acid-protein conjugates with improved stability and delivery capabilities in human cells.

Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Autoencoder design plus a roughly 24-hour cell-free screen tested 500 candidates over five rounds, finding 30 functional AMPs; six were broad-spectrum with no resistance emerging in E. coli.