Bernd Schmeck

First Genome-Scale Metabolic Model for Understanding HMPV-Host Interaction

The paper constructs the first genome-scale metabolic model for HMPV, identifies antiviral targets, and highlights UDP-GlcNAc as a critical metabolic hub for viral replication.

Lifespan Analysis of the Lung Epithelium Reveals Inflammatory Reprogramming and Regenerative Decline

This study analyzes lung epithelial cells across the lifespan in mice, identifying age-related declines in regeneration linked to inflammation and epigenetic changes.

Raman spectroscopy reveals growth phase-dependent molecular differences in bacterial membrane vesicles

This study uses Raman spectroscopy to analyze molecular changes in bacterial membrane vesicles across growth phases, revealing growth-dependent variations in protein-lipid ratios and secondary structure.

Ketone and glycolytic metabolism are key modulators of inflammation during neonatal sepsis

This study shows that inhibiting glycolysis or supplementing ketones can reduce inflammation and improve outcomes in neonatal sepsis by enhancing mitochondrial metabolism and disease tolerance.

Engineering site-specific nucleic acid-protein conjugates by utilizing a natural RNAylation reaction

This paper establishes RNAylation as a method to create site-specific nucleic acid-protein conjugates with improved stability and delivery capabilities in human cells.

Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Autoencoder design plus a roughly 24-hour cell-free screen tested 500 candidates over five rounds, finding 30 functional AMPs; six were broad-spectrum with no resistance emerging in E. coli.