Mareike Lehmann

Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

Lifespan Analysis of the Lung Epithelium Reveals Inflammatory Reprogramming and Regenerative Decline

This study analyzes lung epithelial cells across the lifespan in mice, identifying age-related declines in regeneration linked to inflammation and epigenetic changes.

Local IFNγ signaling contributes to the regenerative decline of aged alveolar progenitor cells

This study shows that local IFNγ signaling in aged lungs impairs alveolar progenitor cell regeneration, and reducing IFNγ levels restores regenerative capacity.

Targeting p16INK4a reverses alveolar epithelial cell dysfunction and induces lung regeneration in emphysema

This study shows that deleting p16INK4a or targeting p16+ cells reverses alveolar epithelial dysfunction and promotes lung regeneration in emphysema.

Single cell decomposition of multicellular aging programs associated with impaired lung regeneration

The paper uses single-cell RNA-seq to analyze aging effects on lung regeneration, identifying immune cell states linked to impaired progenitor function in aged mice.

SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms

The paper develops SenSet, a gene signature for human lung senescence, validated in 3D culture models and identifies cell-type specific senescence mechanisms in aging and disease.

Repeated cigarette smoke exposure attenuates the proliferation rate of primary human lung fibroblasts in vitro

This study shows that repeated cigarette smoke exposure reduces the proliferation of human lung fibroblasts more than single exposure, with early exposure offering some protection against later exposures.

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regeneration

The paper uses single-cell RNA-seq to identify Krt8+ progenitor cells involved in lung regeneration and shows their role in epithelial differentiation and disease.