Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer's disease
Beika Zhu, Andi Wangzhou, Diankun Yu, Tao Li, Rachael Schmidt, Stacy L. De Florencio, Lauren Chao, Yonatan Perez, Lea T. Grinberg, Salvatore Spina, Richard M. Ransohoff, Arnold R. Kriegstein, William W. Seeley, Tomasz Jan Nowakowski, Xianhua Piao
This study shows that ADGRG1 in microglia helps protect against Alzheimer's disease by improving amyloid clearance and reducing pathology.
bioRxiv · Oct 15, 2024 · PreprintNeuroscience