Bringing the Genetically Minimal Cell to Life on a Computer in 4D
Zane R. Thornburg, Andrew K. Maytin, Jiwoong Kwon, Troy A. Brier, Benjamin R. Gilbert, Enguang Fu, Yang-le Gao, Jordan Quenneville, Tianyu Wu, Henry Li, Talia Long, Weria Pezeshkian, Lijie Sun, DANIELA MATIAS DE CARVALHO BITTENCOURT, John I. Glass, , Zaida Ann Luthey-Schulten
A hybrid 4D whole-cell simulation of the minimal bacterium JCVI-syn3A integrates spatial reaction-diffusion, metabolism, polymer chromosome dynamics, and division across a complete 105-minute cell cycle.
Cell · Mar 9, 2026Peer-reviewedBiophysics✦ In-depth digest