Author

Lionel Gissot

University of Iowa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Assay:electrophysiology· 1

Frequent Co-Authors

Christopher A. AherniD· 4 shared Ahmad Al Saneh· 3 shared Aislinn Joanmarie WilliamsiD· 1 shared Alex DouiD· 1 shared Barry LondoniD· 1 shared Bikash Ranjan PattnaikiD· 1 shared Bum‐Rak ChoiiD· 1 shared Christian Anderson· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersNeuroscience

Christopher A. AhernORCID

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4 papers

Recent·Most cited

Programmable Repair of Disease-Causing UGA Stop Codons in Mammalian Brain

Ahmad Al Saneh, Lionel Gissot, Christopher A. Ahern

This paper develops a method to repair UGA stop codons in mammalian brain using sup-tRNA and AAV vectors, showing efficacy with optimized delivery systems.

bioRxiv · Jun 22, 2026 · PreprintNeuroscience

Position-dependent effects of SCN2A premature stop codons on neuronal excitability and behavior

Ahmad Al Saneh, Maria Fernanda Hermosillo Arrieta, Lionel Gissot, Madison O’Bryan, Rui Li, Gordon F. Buchanan, Christopher A. Ahern, Aislinn Joanmarie Williams

This study shows that different SCN2A premature stop codons have distinct effects on neuronal function and behavior in mice, challenging the assumption of uniform haploinsufficiency.

bioRxiv · Oct 30, 2025 · PreprintNeuroscience

Non-canonical Sodium Channel Isoforms Underlie Chamber Specific Cardiac Excitability

Colin J. Clark, Christian Anderson, Alex Dou, Jason M. Dierdorff, Jason D. Galpin, Lionel Gissot, Samantha L. Thompson, Hannah Choi, Jin‐Young Yoon, Daniel T. Infield, Jared M. McLendon, Peter Bronk, Keane Leeds, Ryan L. Boudreau, Bum‐Rak Choi, , Christopher A. Ahern

This study identifies chamber-specific contributions of non-NaV1.5 sodium channel isoforms to cardiac excitability using a chemical-genetic mouse model and electrophysiological recordings.

bioRxiv · Aug 27, 2025 · PreprintPhysiology

Prevenying vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA

Enes Akyüz, Pawan Kumar Shahi, Lionel Gissot, Ahmad Al Saneh, Divya Sinha, Giovanni M. Hanstad, Meha Kabra, Maria A. Fernandez Zepeda, David M. Gamm, Samuel M. Young, Christopher A. Ahern, Bikash Ranjan Pattnaik

This study demonstrates that engineered tRNA can restore vision in a mouse model of Leber Congenital Amaurosis by suppressing a premature termination codon.

bioRxiv · Jul 10, 2025 · PreprintPhysiology