Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection
Thomas J. Wubben, Mercy D. Pawar, Eric Weh, Andrew J. H. Smith, Peter Sajjakulnukit, Li Zhang, Lipeng Dai, Heather M. Hager, Manjunath P. Pai, Costas Andreas Lyssiotis, Cagri G. Besirli
This study shows that activating PKM2 with ML-265 protects photoreceptors from stress-induced apoptosis in vitro and in vivo.
Scientific Reports · Feb 19, 2020Peer-reviewedMolecular Biology