Inactivation of the DREAM complex mimics the molecular benefits of sleep.
Isabela Santos Valentim, Francisco Javier Romero-Expósito, Katjana Schwab, Melike Bayar, Adiya Tauassarova, Konstantin Riege, Lisa Lange, Olivia Engmann, Martin Fischer, María Olmedo, Steve Hoffmann, Maria A. Ermolaeva
This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.
bioRxiv · Jun 26, 2024 · PreprintPhysiology