Author

Melike Bayar

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Isabela Santos ValentimiD· 2 shared Maria A. ErmolaevaiD· 2 shared Adiya Tauassarova· 1 shared Andreas KoeberleiD· 1 shared Fengting SuiD· 1 shared Francisco Javier Romero-ExpósitoiD· 1 shared Handan Melike DönertaşiD· 1 shared Katjana SchwabiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Isabela Santos ValentimORCID

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2 papers

Recent·Most cited

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging.

Tetiana Poliezhaieva, Yuting Li, Prerana Shrikant Chaudhari, Ulas Isildak, Pol Alonso-Pernas, Isabela Santos Valentim, Fengting Su, Lília Espada, Melike Bayar, Li Fu, Andreas Koeberle, Handan Melike Dönertaş, Maria Ermolaeva

The paper identifies a decline in phosphatidylcholine synthesis as a driver of mitochondrial aging that can be reversed by dietary interventions in both worms and human cells.

Nature Communications · Apr 18, 2026Peer-reviewedCell Biology

Inactivation of the DREAM complex mimics the molecular benefits of sleep.

Isabela Santos Valentim, Francisco Javier Romero-Expósito, Katjana Schwab, Melike Bayar, Adiya Tauassarova, Konstantin Riege, Lisa Lange, Olivia Engmann, Martin Fischer, María Olmedo, Steve Hoffmann, Maria A. Ermolaeva

This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.

bioRxiv · Jun 26, 2024 · PreprintPhysiology