María Olmedo

HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans

This study shows HLH-30/TFEB is essential for chromatin reorganization and cell quiescence during starvation in C. elegans, with loss of HLH-30 disrupting cell cycle arrest and causing premature developmental activation.

In vivo functional classification of PTEN variants reveals context-dependent oncogenicity and interindividual variability

The paper assesses PTEN variant functionality across species, showing context-dependent oncogenicity and interindividual variability using C. elegans and cell lines.

A high-throughput assay quantifies thermal scaling of Drosophila development with minute-scale precision

This paper introduces a high-throughput assay to measure Drosophila larval development with minute-scale precision and shows temperature affects developmental timing predictably.

Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

The interplay between Caenorhabditis elegans larval development and Orsay virus infection

This study investigates how Orsay virus infection affects Caenorhabditis elegans larval development and how molting periods influence viral replication.

Inactivation of the DREAM complex mimics the molecular benefits of sleep.

This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.

Desynchrony between events triggers a compensatory delay during C. elegans development

The paper shows that reduced insulin signaling in C. elegans delays cell divisions more than molting, increasing desynchrony and triggering a compensatory delay in the molting program.

Differential regulation of developmental stages supports a linear model for C. elegans postembryonic development

The paper measures developmental stage durations in C. elegans under varied conditions and finds that stages respond differently to environmental factors, supporting a linear progression model.

Neuronal perception of the social environment intergenerationally controls germline development and generation time in C. elegans

The paper shows that neuronal perception of social pheromones in C. elegans affects germline development timing and generation time in offspring.

Social chemical communication determines recovery from L1 arrest via DAF-16 activation

This study shows that social chemical communication via trehalose and DAF-16 activation enhances recovery from L1 arrest in C. elegans.

Prolonged quiescence delays somatic stem cell-like division in Caenorhabditis elegans and is controlled by insulin signalling

This study shows prolonged quiescence in C. elegans L1 larvae delays cell division and is regulated by insulin signaling, with maternal age affecting recovery variability.

Adenylosuccinate Lyase activity in the Purine recycling pathway is essential for developmental timing, germline maintenance and muscle integrity in C. elegans.

This study identifies ADSL's role in purine recycling pathway in C. elegans, linking it to developmental timing, germline maintenance, and muscle integrity.

Combined flow cytometry and high throughput image analysis for the study of essential genes in Caenorhabditis elegans

The paper develops a method to analyze essential genes in C. elegans by combining flow cytometry and high-throughput image analysis to sort and study homozygous lethal mutants.