Hypoxia-Induced Cardiopulmonary Remodeling and Recovery: Critical Roles of the Proximal Pulmonary Artery, Macrophages, and Exercise
Abhay B. Ramachandra, Prapti Sharma, Ruben De Man, Fadi Nikola, Nicole M. Guerrera, Pramath Doddaballapur, Cristina Cavinato, Rira Choi, Micha Sam Brickman Raredon, Jason M. Szafron, Zhen W. Zhuang, Thomas Bärnthaler, A. Justet, Ngozi D. Akingbesote, Nebal S. Abu Hussein, , Edward P. Manning
This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.
bioRxiv · Feb 15, 2025 · PreprintPhysiology