Author

Rira Choi

Yale UniversityORCID 0000-0002-9759-6909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Edward P. ManningiD· 3 shared Nicole M. Guerrera· 3 shared Xiting YaniD· 3 shared A. JustetiD· 2 shared Abhay B. RamachandraiD· 2 shared Jack Di PaloiD· 2 shared Jason M. SzafroniD· 2 shared Meredith S. GwiniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersPhysiology

Edward P. ManningORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Crystalline silica exposure causes latent biomechanical abnormalities along the cardiopulmonary axis

Meredith S. Gwin, Jack Di Palo, Anthony A. Fung, Rira Choi, Péter Hermán, Alexandria Regan, Aishani Nagamalla, Asad A Syed, Theodore Sandow, Ying Sun, Sydney L. Bluestein, Buqu Hu, Yo Sep Shin, Keshav Harpavat, Clemente J. Britto, , Edward P. Manning

This study shows that a single crystalline silica exposure causes subclinical cardiopulmonary abnormalities in mice, with sex-dependent effects on lung mechanics and transcriptomic responses.

bioRxiv · Oct 24, 2026 · PreprintPhysiology

Biological Aging of the Cardiopulmonary System

D K Liu, Pramath Doddaballapur, Zhongyu Cai, Rira Choi, Jack Di Palo, Nicole M. Guerrera, Nebal Abu Hussein, Meredith S. Gwin, Liqin Lin, Siming Zheng, Yuening Zhang, A. Justet, Abhay B. Ramachandra, Xiting Yan, Edward P. Manning

This study quantifies biological cardiopulmonary aging in mice by integrating biomechanics and single-cell transcriptomics, revealing non-linear aging patterns and cell-type-specific gene expression changes.

bioRxiv · Jun 12, 2026 · PreprintPhysiology

Hypoxia-Induced Cardiopulmonary Remodeling and Recovery: Critical Roles of the Proximal Pulmonary Artery, Macrophages, and Exercise

Abhay B. Ramachandra, Prapti Sharma, Ruben De Man, Fadi Nikola, Nicole M. Guerrera, Pramath Doddaballapur, Cristina Cavinato, Rira Choi, Micha Sam Brickman Raredon, Jason M. Szafron, Zhen W. Zhuang, Thomas Bärnthaler, A. Justet, Ngozi D. Akingbesote, Nebal S. Abu Hussein, , Edward P. Manning

This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.

bioRxiv · Feb 15, 2025 · PreprintPhysiology