Jason M. Szafron

This study shows that a single crystalline silica exposure causes subclinical cardiopulmonary abnormalities in mice, with sex-dependent effects on lung mechanics and transcriptomic responses.

This paper develops a multiscale computational model of pulmonary vascular remodeling in PH, showing it can predict pressure, wall thickness, and stiffness changes in response to treatment.

This study compares in vivo and ex vivo lung biomechanics in mice, finding that thoracic structures mainly affect dynamic dissipation and heterogeneity rather than intrinsic elastic properties.

The paper develops HemoLens, a low-cost open-source pressure myography system for characterizing vascular mechanics in native and engineered blood vessels.

This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.

The paper identifies differential proteoglycan dynamics in umbilical artery and vein as the mechanism ensuring rapid arterial closure and venous patency at birth.